Select Agents and Toxins Exclusions:
Excluded Toxins Modified to be Less Potent or Toxic, Section 73.3 (e)

Tetrodotoxin

• Anhydrotetrodotoxin, a derivative of wild-type tetrodotoxin (effective May 15, 2015)
  Experimental evidence suggests that anhydrotetrodotoxin does not possess sufficient acute toxicity to pose a significant public health threat. Anhydrotetrodotoxin has been shown to have a significantly higher LD₅₀ value than tetrodotoxin in a mouse model [Anhydrotetrodotoxin – LD₅₀ (Oral, mouse) = 16.9 mg/kg compared to tetrodotoxin – LD₅₀ (Oral, mouse) = 0.334 mg/kg]

Reference(s):

1. Deguchi T. Structure and activity of tetrodotoxin derivaties. Jpn J Pharmacol. 1967 Jun;17(2):267-78.
2. Kawasaki H, Nagata T, Kanoh S. An Experience on the Biological Assay of the Toxicity of Imported Fugu (Tetrodon). Food Hygiene Journal. 1973. 14, 186.